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KMID : 0371420221030060323
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Annals of Surgical Treatment and Research
2022 Volume.103 No. 6 p.323 ~ p.330
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Comprehensive clinical characterization of patients with BRCA1: c.5017_5019del germline variant
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Bang Yoon-Ju
Kwon Won-Kyung
Kim Jong-Won
Lee Jeong-Eon
Jung Boo-Yeon
Kim Mi-Na
Kim Ji-Sun
An Jeong-Shin
Jung Seung-Pil
Kim Hong-Kyu
Kim Zi-Sun
Youn Hyun-Jo
Ryu Jai-Min
Kim Sung-Won
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Abstract
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Purpose: We provide evidence for the reclassification of the BRCA1:c.5017_5019del variant by presenting the clinicopathological characteristics, clinical outcomes, and family history of breast or ovarian cancer in 17 patients with this variant.
Methods: This study included breast or ovarian cancer patients tested for BRCA1/2 genes between January 2008 and June 2020 at 10 medical centers in Korea. We retrospectively reviewed 17 probands from 15 families who had the BRCA1:c.5017_5019del variant according to the electronic medical records.
Results: We present 10 breast cancer patients and 7 ovarian cancer patients from 15 families identified as having BRCA1:c.5017_5019del and a total of 19 cases of breast cancer and 14 cases of ovarian cancer in these families. The ratio of breast-to-ovarian cancer was 1.3:1. Breast cancer patients with this variant showed a rich family history of breast or ovarian cancer, 8 patients (80.0%). The mean age at diagnosis was 45.4 years and 6 patients (60.0%) were categorized into hormone-receptor?negative breast cancer. Also, the ovarian cancer patients with this variant showed strong family histories of breast and/or ovarian cancer in 4 patients (57.1%).
Conclusion: We presented clinical evidence for the reclassification of BRCA1:c.5017_5019del as a likely pathogenic variant (LPV). Reclassification as LPV could result in the prophylactic treatment and medical surveillance of probands, family testing recommendations, and appropriate genetic counseling of their families.
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KEYWORD
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BRCA1, Breast neoplasms, Genes, Genetic testing, Hereditary breast and ovarian cancer syndrome
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